Ubaldo E Martinez-Outschoorn: search on Z-Library

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1

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P., Sotgia, Federica

Journal:

Seminars in Cancer Biology

Year:

2014

Language:

english

File:

PDF, 3.60 MB

english, 2014

2

Cancer metabolism: a therapeutic perspective

Martinez-Outschoorn, Ubaldo E., Peiris-Pagés, Maria, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2016

Language:

english

File:

PDF, 1.22 MB

english, 2016

3

Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function

Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.

Journal:

Seminars in Oncology

Year:

2014

Language:

english

File:

PDF, 1.69 MB

english, 2014

4

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

Sotgia, Federica, Martinez-Outschoorn, Ubaldo E., Howell, Anthony, Pestell, Richard G., Pavlides, Stephanos, Lisanti, Michael P.

Journal:

Annual Review of Pathology Mechanisms of Disease

Year:

2012

Language:

english

File:

PDF, 3.41 MB

english, 2012

5

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

Martinez-Outschoorn, Ubaldo E., Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S., Howell, Anthony, Pestell, Richar

Journal:

Year:

2011

Language:

english

File:

PDF, 6.86 MB

english, 2011

6

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

Lamb, Rebecca, Ozsvari, Bela, Lisanti, Camilla L., Tanowitz, Herbert B., Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

7

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors

Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Trimmer, Casey, Flomenberg, Neal, Wang, Chenguang, Pavlides, Stephanos, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.

Journal:

Year:

2011

Language:

english

File:

PDF, 6.20 MB

english, 2011

8

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert B., Mutti, Luciano, Krstic-Demonacos, Marija, Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Year:

2016

Language:

english

File:

PDF, 4.02 MB

english, 2016

9

Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity

Bonuccelli, Gloria, Peiris-Pages, Maria, Ozsvari, Bela, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Year:

2017

Language:

english

File:

PDF, 7.85 MB

english, 2017

10

Autophagy in cancer: a complex relationship

Wilde, Lindsay, Tanson, Katherina, Curry, Joseph, Martinez-Outschoorn, Ubaldo

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 1.12 MB

english, 2018

11

Cancer metabolism: a therapeutic perspective

Martinez-Outschoorn, Ubaldo E., Peiris-Pagés, Maria, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2017

File:

PDF, 52 KB

2017

12

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth

Balliet, Renee M., Capparelli, Claudia, Guido, Carmela, Pestell, Timothy G., Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Pestell, Richard G., Howell, Antho

Journal:

Year:

2011

Language:

english

File:

PDF, 2.02 MB

english, 2011

13

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

De Luca, Arianna, Fiorillo, Marco, Peiris-Pagès, Maria, Ozsvari, Bela, Smith, Duncan L., Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E., Cappello, Anna Rita, Pezzi, Vincenzo, Lisanti, Michael P

Journal:

Year:

2015

File:

PDF, 3.43 MB

2015

14

Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Howell, Anthony, Lisanti, Michael P., Sotgia, Federica

Journal:

Year:

2012

Language:

english

File:

PDF, 2.52 MB

english, 2012

15

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K.,

Journal:

Year:

2010

Language:

english

File:

PDF, 2.09 MB

english, 2010

16

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert, Cappello, Anna, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael

Journal:

Year:

2016

File:

PDF, 2.72 MB

2016

17

Mitochondrial Biogenesis Drives Tumor Cell Proliferation

Ubaldo E. Martinez-Outschoorn, Stephanos Pavlides, Federica Sotgia, Michael P. Lisanti

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 757 KB

english, 2011

18

Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Salem, Ahmed F., Tsirigos, Aristotelis, Lamb, Rebecca, Sneddon, Sharon, Hulit, James, Howell, Anthony, Lisanti, Michael P.

Journal:

Year:

2012

Language:

english

File:

PDF, 4.35 MB

english, 2012

19

A Two-Step Approach to Myeloablative Haploidentical Transplantation: Low Nonrelapse Mortality and High Survival Confirmed in Patients with Earlier Stage Disease

Grosso, Dolores, Gaballa, Sameh, Alpdogan, Onder, Carabasi, Matthew, Filicko-O’Hara, Joanne, Kasner, Margaret, Martinez-Outschoorn, Ubaldo, Wagner, John L., O'Hara, William, Rudolph, Shannon, Chervone

Journal:

Biology of Blood and Marrow Transplantation

Year:

2015

Language:

english

File:

PDF, 576 KB

english, 2015

20

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention

Lisanti, Michael P, Reeves, Kimberly, Peiris-Pagès, Maria, Chadwick, Amy L, Sanchez-Alvarez, Rosa, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica

Journal:

Year:

2014

Language:

english

File:

PDF, 5.78 MB

english, 2014

21

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

Avena, Paola, Anselmo, Wanda, Wang, Chenguang, Pestell, Richard G., Lamb, Rebecca S., Casaburi, Ivan, Andò, Sebastiano, Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.50 MB

english, 2013

22

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestel

Journal:

Year:

2011

Language:

english

File:

PDF, 4.28 MB

english, 2011

23

BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment

Martinez-Outschoorn, Ubaldo E., Balliet, Renee, Lin, Zhao, Whitaker-Menezes, Diana, Birbe, Ruth C., Bombonati, Alessandro, Pavlides, Stephanos, Lamb, Rebecca, Sneddon, Sharon, Howell, Anthony, Sotgia,

Journal:

Year:

2012

Language:

english

File:

PDF, 3.05 MB

english, 2012

24

Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma

Roche, Megan E., Lin, Zhao, Whitaker-Menezes, Diana, Zhan, Tingting, Szuhai, Karoly, Bovee, Judith V.M.G., Abraham, John A., Jiang, Wei, Martinez-Outschoorn, Ubaldo, Basu-Mallick, Atrayee

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2020

File:

PDF, 3.91 MB

2020

25

Caveolae and signalling in cancer

Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Nature Reviews Cancer

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

26

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

Federica Sotgia, Ubaldo E Martinez-Outschoorn, Michael P Lisanti

Journal:

Year:

2011

Language:

english

File:

PDF, 257 KB

english, 2011

27

Creating a tumor-resistant microenvironment: Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo

Al-Zoubi, Mazhar, Salem, Ahmed F., Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Lamb, Rebecca, Hulit, James, Howell, Anthony, Gandara, Ricardo, Sartini, Marina, Arafat, Hwyda, Bevilacqua,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.83 MB

english, 2013

28

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

Martinez-Outschoorn, Ubaldo E., Goldberg, Allison F., Lin, Zhao, Ko, Ying-Hui, Flomenberg, Neal, Wang, Chenguang, Pavlides, Stephanos, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti,

Journal:

Cancer Biology & Therapy

Year:

2011

Language:

english

File:

PDF, 4.44 MB

english, 2011

29

Reverse Warburg Effect in a Patient With Aggressive B-Cell Lymphoma: Is Lactic Acidosis a Paraneoplastic Syndrome?

Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Valsecchi, Matias, Martinez-Cantarin, Maria P., Dulau-Florea, Alina, Gong, Jerald, Howell, Anthony, Flomenberg, Neal, Pestell, Richard G., Wagn

Journal:

Seminars in Oncology

Year:

2013

Language:

english

File:

PDF, 3.22 MB

english, 2013

30

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

Federica Sotgia, Ubaldo E Martinez-Outschoorn, Stephanos Pavlides, Anthony Howell, Richard G Pestell, Michael P Lisanti

Journal:

Breast Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

31

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

Chiavarina, Barbara, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pestell, Richard G., Smith, Johanna, Daniel, Rene, Sotgia, Federic

Journal:

Cancer Biology & Therapy

Year:

2011

Language:

english

File:

PDF, 3.86 MB

english, 2011

32

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

Capparelli, Claudia, Whitaker-Menezes, Diana, Guido, Carmela, Balliet, Renee, Pestell, Timothy G., Howell, Anthony, Sneddon, Sharon, Pestell, Richard G., Martinez-Outschoorn, Ubaldo, Lisanti, Michael

Journal:

Year:

2012

Language:

english

File:

PDF, 6.39 MB

english, 2012

33

A Two-Step Haploidentical Versus a Two-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation

Gaballa, Sameh, Palmisiano, Neil, Alpdogan, Onder, Carabasi, Matthew, Filicko-O'Hara, Joanne, Kasner, Margaret, Kraft, Walter K., Leiby, Benjamin, Martinez-Outschoorn, Ubaldo, O'Hara, William, Pro, Ba

Journal:

Biology of Blood and Marrow Transplantation

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

34

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Martinez-Outschoorn, Ubaldo E., Casey, Trimmer, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Zhou, Jie, Wang, Chenguang, Pavlides, Stephanos, Martinez-Cantarin, Maria P., Capozza, Franco,

Journal:

Year:

2010

Language:

english

File:

PDF, 4.48 MB

english, 2010

35

Metabolic Asymmetry in Cancer: A “Balancing Act” that Promotes Tumor Growth

Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Year:

2014

Language:

english

File:

PDF, 306 KB

english, 2014

36

Obinutuzumab, a potent anti–B-cell agent, for rituximab-unresponsive IgM anti-MAG neuropathy

Rakocevic, Goran, Martinez-Outschoorn, Ubaldo, Dalakas, Marinos C.

Journal:

Neurology: Neuroimmunology & Neuroinflammation

Year:

2018

Language:

english

File:

PDF, 247 KB

english, 2018

37

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

Chiavarina, Barbara, Whitaker-Menezes, Diana, Migneco, Gemma, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Tanowitz, Herbert B., Casimiro, Mathew C., Wang, Chenguang, Pestell,

Journal:

Year:

2010

Language:

english

File:

PDF, 3.95 MB

english, 2010

38

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

Ko, Ying-Hui, Lin, Zhao, Flomenberg, Neal, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P., Martinez-Outschoorn, Ubaldo E.

Journal:

Cancer Biology & Therapy

Year:

2011

Language:

english

File:

PDF, 4.06 MB

english, 2011

39

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Peiris-Pagès, Maria, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

Journal:

Cell Metabolism

Year:

2015

Language:

english

File:

PDF, 589 KB

english, 2015

40

Parathyroid Hormone-Related Peptide–Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates

Mills, Teresa Anne, Orloff, Marlana, Domingo-Vidal, Marina, Cotzia, Paolo, Birbe, Ruth C., Draganova-Tacheva, Rossitza, Martinez Cantarin, Maria P., Tuluc, Madalina, Martinez-Outschoorn, Ubaldo

Journal:

Seminars in Oncology

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

41

Haploidentical Transplantation for Peripheral T-Cell Lymphomas: A Single-Institution Experience

Gooptu, Mahasweta, Leiby, Benjamin, Carabasi, Matthew, Filicko-O'Hara, Joanne, Kasner, Margaret, Klumpp, Thomas, Martinez-Outschoorn, Ubaldo, Pro, Barbara, Sharma, Manish, Weiss, Mark, O'Hara, William

Journal:

Biology of Blood and Marrow Transplantation

Year:

2016

Language:

english

File:

PDF, 179 KB

english, 2016

42

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

Pavlides, Stephanos, Vera, Iset, Gandara, Ricardo, Sneddon, Sharon, Pestell, Richard G., Mercier, Isabelle, Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Howell, Anthony, Sotgia, Federica,

Journal:

Antioxidants & Redox Signaling

Year:

2012

Language:

english

File:

PDF, 1021 KB

english, 2012

43

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

Witkiewicz, Agnieszka K., Whitaker-Menezes, Diana, Dasgupta, Abhijit, Philp, Nancy J., Lin, Zhao, Gandara, Ricardo, Sneddon, Sharon, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael

Journal:

Year:

2012

Language:

english

File:

PDF, 1.87 MB

english, 2012

44

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E., Lamb, Rebecca, Hulit, James, Howell, Anthony, Gandara, Ricardo, Sartini, Marina, Rubin, Emanuel, Lisanti, Michael P., Sotgia, Federica

Journal:

Year:

2013

Language:

english

File:

PDF, 2.69 MB

english, 2013

45

Tumor Metabolism in the Microenvironment of Nodal Metastasis in Head and Neck Squamous Cell Carcinoma

Mollaee, Mehri, Cotzia, Paolo, Tassone, Patrick, Johnson, Jennifer, Zhan, Tingting, Cognetti, David, Luginbuhl, Adam, Martinez-Outschoorn, Ubaldo, Curry, Joseph, Tuluc, Madalina

Journal:

American Journal of Clinical Pathology

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015

46

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma With Pancytopenia and Chylothorax

Lisa C. Thomas, Matthew J. Maida, Ubaldo Martinez-Outschoorn, Joanne Filicko-O'Hara, Gloria J. Morris

Journal:

Seminars in Oncology

Year:

2011

Language:

english

File:

PDF, 949 KB

english, 2011

47

Tumor Microenvironment: Introduction

Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P.

Journal:

Seminars in Oncology

Year:

2014

Language:

english

File:

PDF, 42 KB

english, 2014

48

Cancer-Associated Fibroblast Density, Prognostic Characteristics, and Recurrence in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

Knops, Alexander M., South, Andrew, Rodeck, Ulrich, Martinez-Outschoorn, Ubaldo, Harshyne, Larry A., Johnson, Jennifer, Luginbuhl, Adam J., Curry, Joseph M.

Journal:

Frontiers in Oncology

Year:

2020

File:

PDF, 1.84 MB

2020

49

Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery

Lisanti, Michael P., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica

Journal:

Year:

2013

Language:

english

File:

PDF, 2.36 MB

english, 2013

50

Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

Carito, Valentina, Bonuccelli, Gloria, Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Caroleo, Maria Cristina, Cione, Erika, Howell, Anthony, Pestell, Richard G., Lisanti, Michael P., Sotgia

Journal:

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

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